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KMID : 1134120190220020336
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Journal of Breast Cancer
2019 Volume.22 No. 2 p.336 ~ p.340
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Human Epidermal Growth Factor Receptor 2-positive Mucinous Carcinoma with Signet Ring Cell Differentiation, Which Showed Complete Response after Neoadjuvant Chemotherapy
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Jang Yun-Jeong
Cho Eun-Yoon
Cho Soo-Youn
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Abstract
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Mucinous carcinoma (MC) is a rare subtype of breast cancer, which is composed of tumor cells floating in the abundant extracellular mucin. This form of cancer is usually estrogen receptor/progesterone receptor positive and human epidermal growth factor receptor 2 (HER2) negative. Here, we present a case of HER2-positive MC with an unusual signet ring cell differentiation. It is very rare that a breast tumor consists entirely of signet ring cells. The tumor showed pathologic complete response (pCR) after neoadjuvant chemotherapy with trastuzumab and pertuzumab. pCR of HER2-positive MC has rarely been described in literature. It is important to consider the biological heterogeneity of MCs for effective management.
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KEYWORD
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Breast neoplasms, Receptor, ErbB-2, Adenocarcinoma, mucinous, Neoadjuvant therapy, Carcinoma, signet ring cell
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